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Contact: Dr Hannah Keage
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Study aims
Current aims
- To determine the percentages of old people who display dementia-related neuropathological markers (e.g. plaques, tangles, cerebral amyloid angiopathy) relative to the population as a whole and clinical dementia status.
- To investigate the effects of apolipoprotein E (APOE) genotype, age and sex on the relationships between neuropathological markers and clinical dementia status.
- To investigate the effects of ‘brain reserve’ factors such as education, social networks and social class on the relationships between neuropathological markers and clinical dementia status.
- To investigate the relationships between neuropathological markers and behavioural and psychological symptoms of dementia (e.g. anger and irritability).
- To characterise those who age and die without developing clinical dementia in terms of neuropathological markers and longitudinal clinical symptomatology.
Future aims
Brain tissue (frozen and fixed) and blood samples were collected in each of the three studies involved in EClipSE. It is hoped that EClipSE will have funding to enable access to these samples to carry out further neuropathological and genetic work. Of particular interest is:
- The investigation of relationships between genome wide analysis results and gene expression in the brain.
- The investigation of new pathological markers of dementia such as TAR DNA binding protein (TDP-43).
- Better characterisation of neuropathological markers already part of the EClipSE database such as vascular pathologies.