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Data
Introduction
Summary of data that forms the EClipSE database
Some data were collected identically across the original studies while for other data there were differences between their collections. For example, as Vantaa 85+ participants were assessed by a neurologist, clinical diagnoses are available for conditions such as high blood pressure and diabetes while these conditions were self-reported by CFAS and CC75C participants. Even for data collected identically across the original studies, there are differences due to geography. For example, due to educational systems differing between the UK and Finland in the early and mid 20th century, CFAS and CC75C completed an average of 9 years of formal education while Vantaa participants completed only 4. These data differences guide analyses within the context of research hypotheses.
There are currently 970 participants in Version 1 of the EClipSE database. However, as brain donation is ongoing in the CFAS and the CC75C study, numbers will increase in the future. The following figure details the characteristics of the EClipSE sample in terms of age, original study, dementia status and sex.
Below is a summary of data that forms the EClipSE database.
Basic details and socio-demographic
Centre/study code
Participant ID
Date of examination/assessment
Date of birth
Age at examination/assessment
Sex
Marital status
Number of years of education
Social class
Frequency of family and friend contact
Participation - non-religious
Participation - religious
Accommodation
Others living with subject
Physical health
Dementia classification
Self reported health
Vision
Hearing
Appetite
Weight loss
Falls
Arthritis and rheumatism
Thyroid function
Parkinson’s disease
Tremor
Diabetes
Epilepsy
Heart attack
High blood pressure
Low blood pressure
Headaches and migraine
Stroke and transient Ischemic Attack
Angina
Snoring
General sleeping difficulties
Sleep onset insomnia type symptoms
Sleep maintenance type symptoms
Head injury
Smoking - present
Smoking - past/ever
Alcohol - present
Alcohol - past/ever
Alcohol problem
Activities and instruments of daily living
Shopping
Cooking
Feeding
Household tasks
Housework
Laundry
Walking
Mobility
Transportation use
Bath/shower
Up-and-down reaching
Dressing
Activities requiring fine motor movements
Toilet
Money
Medicine use
Cognition
Mini Mental State Examination (MMSE)
Concentration and attention difficulties
General memory difficulties
Indecisive
General mental functioning / muddled
Speech problems
Psychiatric symptoms
Anxiety / fright
Autonomic symptoms of anxiety
Restlessness
Tiredness / exhaustion
Life satisfaction
Loneliness
Depression
Lost interest in life
Life without meaning
Suicidal thoughts
View of future
Delusions
Hallucinations
Irritability / anger
Genetics
Apolipoprotein E (APOE) genotype
Neuropathology
Date of post mortem (PM)
PM interval (hours)
Brain weight
Cortical atrophy
Location of cortical atrophy [Frontal (F), Temporal (T), Hippocampus (H), Parietal (P), Occipital (O), Cerebellum (C)]
Pallor of substantia nigra
Other non-vascular Central Nervous System (CNS) lesions
Vascular disease - gross findings
Vessels: atherosclerosis
Vessels: 90% stenosis of obstruction
Parenchymal vascular lesions
Types of lesions: lacune
Types of lesions: infarct
Types of lesions: haemorrhage
Types of lesions: infarcts +/>10mm
Types of lesions: lacunes <10mm
Types of lesions: haemorrhages
Atherosclerosis
Arteriolar sclerosis
V-R space expansion
Perivascular gliosis
White matter pallor
Other microvascular disease
Hippocampus and entorhinal cortex
Plaques: neuritic
Plaques: diffuse
Tangles
Cerebral amyloid angiopathy (CAA): parenchymal
CAA: meningeal/vascular
Granulovacolar degeneration
Hirano bodies
Neuronal loss
Gliosis
Pick bodies
Lewy bodies
Neocortex (inc. F, T, P, O)
Plaques: neuritic
Plaques: diffuse
Tangles
CAA: parenchymal
CAA: meningeal/vascular
Granulovacolar degeneration
Hirano bodies
Neuronal loss
Gliosis
Pick bodies
Lewy bodies
Brainstem [inc. Substantia Niagra (SN), Nucleus Basalis (NB), Raphe Nucleus (RD), Locus Coeruleus (LC), Vagus Nerve (VN)]
Neuronal loss
Gliosis
Pigmentary incontinence
Lewy bodies
Tangles
Plaques
Other
Other neuropathology
CERAD diagnosis
Braak stage